| Primary Identifier | MGI:108442 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12877 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR AU-rich region binding activity and mRNA regulatory element binding translation repressor activity. Involved in cellular response to amino acid stimulus; cellular response to hypoxia; and regulation of translation. Acts upstream of or within regulation of neuronal synaptic plasticity; regulation of translation; and synaptonemal complex assembly. Located in several cellular components, including cytoplasm; meiotic spindle; and nucleus. Is active in glutamatergic synapse. Is expressed in central nervous system; early embryo; reproductive system; and sensory organ. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). PHENOTYPE: Mice homozygous for a null allele are viable and overtly normal but display a developmental arrest of both female and male germ cells at the pachytene stage, defective synaptonemal complex formation, and impaired neuronal synaptic plasticity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
