Primary Identifier | MGI:1914398 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 67148 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity and enzyme activator activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Predicted to be part of mRNA cap methyltransferase RNMT:RAMAC complex and mRNA capping enzyme complex. Is expressed in embryo. Orthologous to several human genes including RAMAC (RNA guanine-7 methyltransferase activating subunit). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic growth retardation, small egg cylinders, disorganized extraembryonic tissue, failure of primitive streak formation and gastrulation, and complete embryonic lethality by E9.5. [provided by MGI curators] |