| Primary Identifier | MGI:109354 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 22228 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GDP binding activity. Involved in several processes, including cellular response to glucose stimulus; macrophage differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). PHENOTYPE: Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
