| Primary Identifier | MGI:3769724 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 791260 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables catechol O-methyltransferase activity. Involved in several processes, including auditory receptor cell development; catecholamine catabolic process; and positive regulation of protein import. Located in apical part of cell and endoplasmic reticulum. Used to study autosomal recessive nonsyndromic deafness 63. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to several human genes including LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing) and TOMT (transmembrane O-methyltransferase). PHENOTYPE: Mice homozygous for a mutation of this gene exhibit marked hyperactivity, bidirectional circling and head-tossing. These behaviors are suppressed during sleep and nursing. Homozygous mutant males exhibit heightened male:male aggression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
