| Primary Identifier | MGI:5474850 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 101488143 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including heme binding activity; hemoglobin binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to be located in extracellular space. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in blood; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; congenital hemolytic anemia (multiple); polycythemia (multiple); sickle cell disease (multiple); and thalassemia (multiple). Orthologous to several human genes including HBB (hemoglobin subunit beta). |
| specificity | C57BL/6 mice (reference assembly) has a haplotype known as - single, where the two adult beta-globin genes are highly similar to each other, and they are called beta-s (Hbb-bs) and beta-t (Hbb-bt). Other mouse strains such as BALB/c or 129/SvJ have a haplotype known as - diffuse, where the two adult genes, known as beta-major (Hbb-b1) andbeta-minor (Hbb-b2), are different from each other (J:32353; J:28981). |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
