| Primary Identifier | MGI:1346320 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 24075 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and promoter-specific chromatin binding activity. Involved in several processes, including allantois development; chordate embryonic development; and protein-containing complex assembly. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; apoptotic process; and hepatocyte differentiation. Located in male germ cell nucleus. Part of transcription preinitiation complex. Is active in nucleus. Is expressed in several structures, including alimentary system; blastocyst; embryo mesenchyme; nervous system; and sensory organ epithelium. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). PHENOTYPE: Homozygous null mice die shortly after implantation. Embryos are developmentally retarded and disorganized, the inner cell mass is small and trophoblasts stop endocycling. Ablation in keratinocytes during fetal development, but not in adult keratinocytes, results in impaired skin barrier function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
