Primary Identifier | MGI:2152419 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 117229 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein serine/threonine kinase activity. Involved in manchette assembly and protein autophosphorylation. Located in manchette. Is expressed in several structures, including central nervous system; heart; lung; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. Orthologous to human STK33 (serine/threonine kinase 33). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with abnormal sperm flagellum morphology and asthenozoospermia. [provided by MGI curators] |