Primary Identifier | MGI:1928820 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 56787 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; salivary gland development; and sensory epithelium regeneration. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in parotid gland; sublingual gland; submandibular gland; and ureter. Orthologous to human ASCL3 (achaete-scute family bHLH transcription factor 3). PHENOTYPE: Mice heterozygous for a null allele are born at the expected frequency and exhibit normal growth, fertility, survival and salivary gland function. [provided by MGI curators] |