Primary Identifier | MGI:103075 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 22390 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein kinase activity. Acts upstream of or within establishment of cell polarity; microtubule cytoskeleton organization; and neuron projection morphogenesis. Located in cytoplasm. Is expressed in several structures, including brain ventricular layer; early embryo; gut; humerus; and inferior colliculus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase). PHENOTYPE: Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function. [provided by MGI curators] |