Primary Identifier | MGI:1914172 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 66922 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within Ras protein signal transduction and positive regulation of Schwann cell migration. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; cerebral cortex; lung; metanephros; and thymus primordium. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2). PHENOTYPE: Mice homozygous for a gene trap insertion exhibit retinal degeneration, and increased total body mass and total body fat. [provided by MGI curators] |