| Primary Identifier | MGI:1924285 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 77035 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and p53 binding activity. Involved in circadian regulation of gene expression and protein destabilization. Acts upstream of or within several processes, including fibroblast proliferation; regulation of DNA-binding transcription factor activity; and regulation of signal transduction by p53 class mediator. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and trachea. Orthologous to human KDM8 (lysine demethylase 8). PHENOTYPE: Homozygous inactivation of this gene leads to complete embryonic lethality during organogenesis associated with severe growth retardation and abnormal embryo turning. Observed phenotypes include open neural tubes and absent vitelline blood vessels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
