Primary Identifier | MGI:1916286 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 69036 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables peptidoglycan binding activity. Acts upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in mucus layer. Orthologous to human ZG16 (zymogen granule protein 16). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased bacterial penetrance into the inner mucus layer of the colon, increased bacterial loads in draining lymph nodes and the spleen and increased abdominal fat mass. [provided by MGI curators] |