Primary Identifier | MGI:2676877 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 387198 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within cellular response to lipopolysaccharide and male sex differentiation. Is expressed in gonad and urogenital sinus. Orthologous to human MIR202 (microRNA 202). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced male fertility associated with decreased testis size, oligozoospermia, impaired spermatogenesis, spermatocyte apoptosis, and multiple defects during meiosis prophase I, including inter-sister synapsis and impaired crossover formation. Female fertility is normal. [provided by MGI curators] |