| Primary Identifier | MGI:1339364 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 17831 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) An extracellular matrix structural constituent. Involved in host-mediated regulation of intestinal microbiota composition; maintenance of gastrointestinal epithelium; and mucus secretion. Acts upstream of or within several processes, including glandular epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is active in mucus layer. Is expressed in hindgut epithelium and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (mucin 2, oligomeric mucus/gel-forming). PHENOTYPE: Homozygotes for a point mutation have soft feces at weaning and develop diarrhea associated with malapsorption syndrome. Homozygous null mutants pass blood in their feces at 6 months, and 65% of null mutants have intestinal tumors at 1 year. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
