| Primary Identifier | MGI:96434 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16002 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; embryonic placenta development; and positive regulation of developmental growth. Acts upstream of or within several processes, including exocrine pancreas development; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study type 1 diabetes mellitus 2. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). PHENOTYPE: Mutations that are paternally transmitted result in growth deficiency. Heterozygous mice inheriting a mutant allele from their mother appear to be phenotypically normal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
