Primary Identifier | MGI:1926855 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 63830 |
Mgi Type | lncRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and miRNA binding activity. Involved in several processes, including apoptotic process involved in development; cell migration; and osteoblast proliferation. Acts upstream of or within genomic imprinting and negative regulation of gene expression via chromosomal CpG island methylation. Is expressed in several structures, including extraembryonic component; heart; lens; liver; and placenta. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome. Orthologous to human KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1). PHENOTYPE: Mice heterozygous for any of several independently generated targeted alleles exhibit abnormal imprinting and may display a growth deficiency. [provided by MGI curators] |