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ncRNA Gene : Kcnq1ot1 KCNQ1 overlapping transcript 1

Primary Identifier  MGI:1926855 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  63830
Mgi Type  lncRNA gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables chromatin binding activity and miRNA binding activity. Involved in several processes, including apoptotic process involved in development; cell migration; and osteoblast proliferation. Acts upstream of or within genomic imprinting and negative regulation of gene expression via chromosomal CpG island methylation. Is expressed in several structures, including extraembryonic component; heart; lens; liver; and placenta. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome. Orthologous to human KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1).
PHENOTYPE: Mice heterozygous for any of several independently generated targeted alleles exhibit abnormal imprinting and may display a growth deficiency. [provided by MGI curators]
  • synonyms:
  • KCNQ1 overlapping transcript 1,
  • Kcnq1ot1,
  • MGI:1930304,
  • tumor-suppressing subchromosomal transferable fragment 8,
  • Tssc8,
  • Lit1,
  • Kvlqt1-as

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Canonical gene --> Transcripts in specific strains.

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