| Primary Identifier | MGI:99695 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 13043 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including Arp2/3 complex binding activity; profilin binding activity; and proline-rich region binding activity. Involved in intracellular protein transport and regulation of mitophagy. Acts upstream of or within dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Part of voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and sensory organ. Orthologous to human CTTN (cortactin). PHENOTYPE: Mice homozygous for one knock-out allele exhibit abnormal early zygote development and die prior to the 2-cell stage. Mice homozygous for a different knock-out allele exhibit increased permeability in vascular and lung endothelial cells and impaired neutrophil extravasation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
