Primary Identifier | MGI:2443003 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 234069 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity and double-stranded DNA binding activity. Involved in several processes, including positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of DNA-templated transcription; and spleen development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Is expressed in lung; nervous system; retina layer; and skeletal muscle. Orthologous to human PCID2 (PCI domain containing 2). PHENOTYPE: Homozygotes for a targeted null mutation implant, but die prior to embryonic day 7.5. Heterozygotes also exhibit excess embryonic loss. [provided by MGI curators] |