| Primary Identifier | MGI:88114 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 11945 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATPase activator activity and P-type potassium:proton transporter activity. Predicted to contribute to heterocyclic compound binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and pH reduction. Predicted to act upstream of or within protein glycosylation and regulation of proton transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Is expressed in alimentary system; stomach; stomach epithelium; stomach fundus; and stomach mucosa. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). PHENOTYPE: Mice homozygous for disruptions in this gene are superficially normal but have hypertrophied stomach mucosa, neutral luminal pH in the stomach, and hypergastrinemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
