| Primary Identifier | MGI:1096878 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 13214 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable CCR6 chemokine receptor binding activity and identical protein binding activity. Involved in innate immune response and response to bacterium. Predicted to be located in membrane; microvesicle; and sperm midpiece. Predicted to be active in extracellular space. Is expressed in epidermis and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and lung disease. Orthologous to human DEFB1 (defensin beta 1). PHENOTYPE: Mice homozygous for a null allele exhibit a reduction in bacterial clearance and increased bacterial urine content. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
