| Primary Identifier | MGI:103267 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 13685 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables eukaryotic initiation factor 4E binding activity. Involved in IRES-dependent translational initiation of linear mRNA. Acts upstream of or within cellular response to dexamethasone stimulus; insulin receptor signaling pathway; and negative regulation of translational initiation. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; oocyte; pancreas tip epithelium; skeletal musculature; and thymus. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). PHENOTYPE: Homozygotes for a targeted mutation display hypoglycemia and hypoleptinemia with significantly reduced white fat pads and a notable increase in metabolic rate. Male white adipose tissue exhibits the multilocular appearance of brown adipocytes, and expresses UCP1, a specific marker of brown fat. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
