Primary Identifier | MGI:1916117 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 68867 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF122 (ring finger protein 122). PHENOTYPE: Mice homozygous for a null allele display decreased susceptibility to Riboviria infection induced morbidity/mortality with altered expression of interferons and interleukin 6. [provided by MGI curators] |