| Primary Identifier | MGI:1934816 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 104271 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within with a positive effect on DNA methylation-dependent constitutive heterochromatin formation. Acts upstream of or within several processes, including male genitalia development; meiotic nuclear division; and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
