Primary Identifier | MGI:1891346 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 80857 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable fibroblast growth factor receptor binding activity; growth factor activity; and receptor-receptor interaction. Involved in regulation of neuron differentiation. Acts upstream of or within inner ear auditory receptor cell differentiation and regulation of cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including cranium; jaw; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human FGF20 (fibroblast growth factor 20). PHENOTYPE: Mice homozygous for a knock-out allele exhibit imapired coclear lateral compartment differentiation and deafness without loss of vestibular function. [provided by MGI curators] |