Primary Identifier | MGI:106684 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 110877 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoamine:proton antiporter activity. Involved in serotonin uptake. Is active in synapse. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased neuron apoptosis, decreased neuron proliferation and impaired spatial object recognition. [provided by MGI curators] |