| Primary Identifier | MGI:2149330 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 114479 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sodium:iodide symporter activity. Predicted to be involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to forskolin; and iodide transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced T3 and T4 levels when fed a minimal iodine diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
