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Protein Coding Gene : Clgn calmegin
Primary Identifier  MGI:107472 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  12745
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables protein folding chaperone. Acts upstream of or within binding activity of sperm to zona pellucida and protein-containing complex assembly. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; gallbladder; genitourinary system; and limb segment. Orthologous to human CLGN (calmegin).
PHENOTYPE: Males homozygous for a targeted null mutation exhibit severely impaired fertility associated with an apparent defect in either sperm/zona pellucida binding and/or sperm transit to the oviduct. [provided by MGI curators]
  • synonyms:
  • A2/6,
  • MGD-MRK-36039,
  • 4930459O04Rik,
  • MGI:2142583,
  • expressed sequence AI528775,
  • Clgn,
  • MGD-MRK-2017,
  • calnexin-t,
  • RIKEN cDNA 4930459O04 gene,
  • Cln,
  • calmegin,
  • MGI:1922128,
  • AI528775
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Features --> Cross References

Genome

Sequence Feature Displayer

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Gene --> Protein-Protein Interactions

Expression

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Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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33 Driver For

Trail: ProteinCodingGene




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