Primary Identifier | MGI:1931874 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 81489 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein folding chaperone. Involved in protein folding. Acts upstream of or within chaperone cofactor-dependent protein refolding. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and sperm head. Predicted to be active in cytosol; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including central nervous system and eye. Orthologous to human DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile, and overtly normal; however, homozygous null peritoneal macrophages display impaired thermotolerance in the early (but not in the late) phase after mild heat treatment. [provided by MGI curators] |