| Primary Identifier | MGI:97592 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 18747 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ATP binding activity; cAMP-dependent protein kinase activity; and metal ion binding activity. Involved in several processes, including cellular response to glucagon stimulus; positive regulation of insulin secretion; and regulation of carbohydrate metabolic process. Acts upstream of with a positive effect on protein export from nucleus. Acts upstream of or within several processes, including cellular response to parathyroid hormone stimulus; embryonic morphogenesis; and protein phosphorylation. Located in several cellular components, including acrosomal vesicle; ciliary base; and sperm flagellum. Part of cAMP-dependent protein kinase complex. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculature. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; and primary pigmented nodular adrenocortical disease 4. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha). PHENOTYPE: Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
