| Primary Identifier | MGI:1921916 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 74666 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables damaged DNA binding activity. Involved in meiosis I; protein localization to site of double-strand break; and spermatogenesis. Located in chromosome. Is active in site of double-strand break. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; meninges; nasal epithelium; and thoracic segment skeleton. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). PHENOTYPE: Homozygous knockout affects chromosomal synapsis, double-stranded DNA break repair and chiasmata formation, resulting in abnormal meiosis, which in turn leads to small testes and male sterility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
