| Primary Identifier | MGI:1349766 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 26992 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription corepressor activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of gene expression. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired cognitive behavior and dendrite morphology in the medial prefrontal cortex as well as male infertility with azoospermia and globozoospermia. Mice homozygous for a different knock-out allele die in utero prior to E16.5, showing fetal growth retardation and altered limb, blood vessel and organ development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
