| Primary Identifier | MGI:1270850 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 20538 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables neurotransmitter transmembrane transporter activity and norepinephrine:sodium symporter activity. Involved in neurotransmitter reuptake and norepinephrine uptake. Acts upstream of or within neurotransmitter transport and response to pain. Predicted to be located in cell surface. Predicted to be active in axon; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; lip; nervous system; renal pelvis; and sensory organ. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2). PHENOTYPE: Norepinephrine homeostasis is abnormal in homozygous mutant mice. In addition to displaying altered behavior, mutant mice are hypersensitive to psychostimulants. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
