| Primary Identifier | MGI:88378 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12623 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable carboxylesterase activity; retinyl-palmitate esterase activity; and sterol ester esterase activity. Predicted to be involved in several processes, including negative regulation of cholesterol storage; positive regulation of cholesterol efflux; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in cranium; hindlimb long bone; lung; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipogenesis accompanied with insulin resistance, hyperinsulinemia, and decreased energy expenditure; as a result, they become obese even on a standard chow diet and develop hepatic steatosis and hyperlipidemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
