| Primary Identifier | MGI:1340051 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 14766 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). PHENOTYPE: Mice homozygous for a null allele exhibit defects in basement membranes of mutltiple tissues, resulting in neuronal ectopias in the frontoparietal cortex, male subfertility and testis defects, brain development, and hematopoietic stem cell development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
