| Primary Identifier | MGI:2142888 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 97487 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be active in membrane. Is expressed in gut; nose; submandibular gland primordium; and urinary system. Orthologous to human CMTM4 (CKLF like MARVEL transmembrane domain containing 4). PHENOTYPE: Mice homozygous for a knock-out allele show decreased daily sperm production and progressive sperm motility, abnormal spermatozoa with backward-curved heads or bent midpieces, and male subfertility. Mice homozygous for a different knock-out allele show a decreased inflammatory response to IL-17A administration and decreased susceptibility to experimental psoriasis but not to experimental autoimmune encephalomyelitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
