| Primary Identifier | MGI:2384561 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234664 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein heterodimerization activity and ubiquitin protein ligase binding activity. Predicted to contribute to NEDD8 activating enzyme activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Is expressed in central nervous system; heart; and retina. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). PHENOTYPE: Mice homzogyous for a conditional allele activated in adult excitatory forebrain neurons exhibit decreased dendritic spine and size, and impaired CNS synaptic transmission, spatial working memory, and short and long term object recognition. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
