| Primary Identifier | MGI:1925938 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 78688 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables death effector domain binding activity and death receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; negative regulation of programmed cell death; and regulation of signal transduction. Acts upstream of or within regulation of gene expression; response to hypoxia; and response to injury involved in regulation of muscle adaptation. Located in mitochondrion and sarcoplasm. Is expressed in adrenal gland; brain; lung; metanephros; and musculature. Orthologous to human NOL3 (nucleolar protein 3). PHENOTYPE: Homozygous null mice exhibit accelerated cardiomyopathy in response to pressure overload and increased myocardial infarct size after I/R injury. Mice homozygous for another knock-out allele exhibit attenuated pulmonary hypertension and vasculature remodeling response to chronic hypoxia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
