| Primary Identifier | MGI:1195972 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 21750 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables double-stranded telomeric DNA binding activity and protein homodimerization activity. Involved in negative regulation of telomere maintenance via recombination and telomeric loop formation. Acts upstream of or within in utero embryonic development; positive regulation of telomere maintenance; and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region and male germ cell nucleus. Part of telomere cap complex. Is expressed in brain; future brain; genitourinary system; heart; and liver. Used to study xeroderma pigmentosum. Orthologous to human TERF2 (telomeric repeat binding factor 2). PHENOTYPE: Homozygous null mice display embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
