Primary Identifier | MGI:2676825 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 387158 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including cellular response to lipopolysaccharide; myelination; and sensory perception of sound. Part of RISC complex. Is expressed in several structures, including autopod; jaw; limb bud; sensory organ; and skeleton. Used to study osteochondrodysplasia. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Nishimura type and thoracic aortic aneurysm. Orthologous to human MIR140 (microRNA 140). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased stature, body weight, and long bone length, cranofacial defects, and osteoarthritis. [provided by MGI curators] |