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Protein Coding Gene : Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Primary Identifier  MGI:1298205 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  20539
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables L-amino acid transmembrane transporter activity. Involved in L-leucine transport. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; cochlea; early conceptus; limb; and reproductive system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5).
PHENOTYPE: Mice homozygous for a targeted mutation die prenatally. [provided by MGI curators]
  • synonyms:
  • Slc7a5,
  • Gm42049,
  • LAT1,
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 5,
  • TA1,
  • D0H16S474E,
  • predicted gene, 42049,
  • MGI:5624934,
  • DNA segment, human S474E
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