Primary Identifier | MGI:2448549 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 234854 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cyclin-dependent protein kinase activity. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be located in ciliary basal body. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human CDK10 (cyclin dependent kinase 10). PHENOTYPE: Mice homozygous for a knock-out allele exhibit severe growth retardation, neonatal lethality, spine malformations and defects in lung, heart, liver and spleen. [provided by MGI curators] |