Primary Identifier | MGI:109322 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 16525 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity; protein heterodimerization activity; and voltage-gated monoatomic ion channel activity. Involved in chloride transmembrane transport; glutamate secretion; and potassium ion transmembrane transport. Located in endosome and plasma membrane. Part of inward rectifier potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). PHENOTYPE: Mice homozygous for a null mutation reduced urinary flow rates and on a low phosphate diet display an attenuated ability to increase renal phosphate reabsorption. [provided by MGI curators] |