| Primary Identifier | MGI:1340026 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17386 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables metalloendopeptidase activity. Involved in several processes, including bone mineralization; endochondral ossification; and extracellular matrix disassembly. Acts upstream of or within collagen catabolic process and growth plate cartilage development. Predicted to be located in intercellular canaliculus. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; connective tissue; inner ear; limb; and skeletal system. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Orthologous to human MMP13 (matrix metallopeptidase 13). PHENOTYPE: Homozygous null mice display increased width of hypertrophic chondrocyte zone and increased trabecular bone. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
