| Primary Identifier | MGI:97010 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17392 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to reactive oxygen species; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein catabolic process. Acts upstream of or within cellular response to amino acid stimulus and regulation of cell migration. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; articular cartilage; axial skeleton thoracic region; branchial arch; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3). PHENOTYPE: Mice homozygous for disrutptions in this gene display abnormalities of the immune system as well as minor structural abnormalities in the neuromuscular junction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
