Primary Identifier | MGI:3606484 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 244694 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin DNA binding activity; damaged DNA binding activity; and histone H3K9 demethylase activity. Acts upstream of or within DNA damage response. Located in nucleus; pericentric heterochromatin; and site of double-strand break. Orthologous to human KDM4D (lysine demethylase 4D). PHENOTYPE: Mice homozygous for a knock-out allele exhibit accumulation of histone 3 methylation in spermatids, a transient increase in testes size, wider tubules, occasional male germ cell apoptosis, and decreased body weight. However, fertility is normal. [provided by MGI curators] |