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Protein Coding Gene : Izumo1r IZUMO1 receptor, JUNO
Primary Identifier  MGI:1929185 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  64931
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables protein binding activity involved in heterotypic cell-cell adhesion; signaling receptor activity; and signaling receptor binding activity. Involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; immune system; and liver and biliary system. Orthologous to human IZUMO1R (IZUMO1 receptor, JUNO).
PHENOTYPE: Homozygous inactivation of this gene causes female infertility. Homozygous null eggs do not fuse with normal sperm. [provided by MGI curators]
  • synonyms:
  • expressed sequence C86255,
  • Izumo1r,
  • folate receptor 4 (delta),
  • MGI:1915662,
  • C86255,
  • Folr4,
  • MGI:2143432,
  • Folbp3,
  • Juno,
  • 0910001L11Rik,
  • RIKEN cDNA 0910001L11 gene,
  • IZUMO1 receptor, JUNO
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