| Primary Identifier | MGI:1913208 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 59035 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in nuclear receptor-mediated steroid hormone signaling pathway; positive regulation of fat cell differentiation; and regulation of intracellular estrogen receptor signaling pathway. Acts upstream of or within several processes, including estrogen receptor signaling pathway; regulation of DNA-templated transcription; and regulation of growth plate cartilage chondrocyte proliferation. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; gonad; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). PHENOTYPE: Homozygous null fetuses are small and die perinatally, whereas heterozygotes are born at the expected Mendelian ratio but show decreased survival through weaning. Mice homozygous for a kinase null allele exhibit neonatal lethality, arrested T cell development, and impaired adipogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
