| Primary Identifier | MGI:2687406 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 399548 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables voltage-gated sodium channel activity. Acts upstream of or within establishment of localization in cell and sodium ion transmembrane transport. Located in intercalated disc. Is expressed in brain; dorsal striatum; and ventral striatum. Human ortholog(s) of this gene implicated in long QT syndrome 10. Orthologous to human SCN4B (sodium voltage-gated channel beta subunit 4). PHENOTYPE: Homozygous null mice exhibit depolarizing shifts in action potential thresholds in core accumbens medium spiny neurons, and reduced ability to induce spike-timing-dependent long-term depression (tLTD). Amphetamine-induced locomotor activity is reduced in male mutant mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
