| Primary Identifier | MGI:88049 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 11806 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Acts upstream of or within several processes, including adrenal gland development; cholesterol efflux; and steroid metabolic process. Located in extracellular space. Is expressed in several structures, including adrenal gland; gonad; gut; liver; and lung. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
