| Primary Identifier | MGI:1889272 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 54725 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables PDZ domain binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and synapse organization. Acts upstream of or within bone development; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and unidimensional cell growth. Located in several cellular components, including basolateral plasma membrane; dendrite; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including central nervous system; metanephros; peripheral nervous system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). PHENOTYPE: Homozygous mutant male mice show infertility due to block in maturation of spermatogenesis. Mice homozygous for a gene trap allele exhibit decreased body size, impaired T cell development, and impaired T cell response to anti-CD3/CD28 antibody stimulation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
